Composition:

Monosaccharide sugars, sodium chloride, natural trace essential minerals from sea salts, buffered with sodium salts of organic acids and purified water.

Action:

This nutritional solution for wound healing is based on research which showed normal or beneficial bacteria of the skin and mucous membranes inhibit pathogenic bacteria. It was demonstrated that monosaccharide sugars and their metabolites were involved with this natural inhibition of pathogenic bacteria by the normal bacterial flora. (1) Further research showed that monosaccharide sugars and their metabolites seemingly increased vascularization and circulation to injured tissues and significantly accelerated the healing of wounds. (2)  Recent research by other workers has confirmed that specific sugars can indeed prevent pathogenic bacteria from infecting mucosal and epithelial cells(3) and significantly stimulate wound healing. (4)

Normal bacterial flora or beneficial bacteria are present on the skin and mucous membranes of organs exposed to the external surface of the body. Antimicrobials and disinfectants may readily destroy beneficial bacteria and inhibit wound healing. Then super-bacterial infections are common sequelae. By maintaining the beneficial bacteria, they can compete with and inhibit the growth of pathogenic bacteria and fungi. This inhibition is an important natural defense mechanism that protects mucous membranes, epidermal surfaces and wounds from pathogenic organisms.

The mechanism of action by which Woundade ™ enhances the natural healing of wounds is unknown. The healing of wounds is complicated and involves a series of steps with several cell types releasing growth factors that promote and maintain the vascular system to damaged tissues. Tissues deprived of adequate circulation will not heal properly and are more likely to become infected with pathogenic bacteria and fungi that further compromise the healing of wounds.

Wound healing involves three essential phases. First, the contraction of injured tissues occurs to close the wound. The second phase is neovascularization, fibroplasia or granulation to remodel and replace lost tissues. The final phase is epithelization and contraction of skin. Pathogenic bacteria, fungi, or inhibitory substances like antimicrobials or disinfectants, and anti-inflammatory agents may interfere with any phase of healing. Woundade ™ has been shown to enhance all three phases of the natural wound healing process. Wounds of the skin and subcutaneous tissues are sites where pathogenic bacteria can enter the blood stream and may produce systemic infections. Rapid wound healing is of utmost importance as there is currently an emergence of numerous antimicrobial resistant strains of super-bacteria and fungi that may be resistant to all antimicrobials. Woundade ™ is formulated with proprietary monosaccharide sugars that provide a natural barrier against pathogenic bacteria and fungi, and also enhance the healing of wounds.

Indications:

Woundade ™ can be applied to wounds of all types including burns, surgical incisions, cuts and trauma, and can be applied to the skin, oral mucosa, gingiva, cornea and mucous membranes of the eyes, subcutaneous tissues and muscles. Apply Woundade ™ immediately after an injury, especially wounds caused by burns. Also, Woundade ™ may be used to accelerate the healing of infected and chronic wounds. In chronic wounds, there may be excessive granulation tissue which should be surgically removed, and then apply Woundade ™ immediately to the fresh wound.

Dosage and administration:

Apply Woundade ™ two to three times daily. For more rapid healing of fresh wounds, Woundade ™ may be applied more often. Woundade ™ may be used with or without bandages. For optimal healing, the wound should be left open to fresh air, cleansed and debrided only with sterile water or saline. Woundade ™ has been formulated to be used alone on wounds and should not be used with any other material that may inhibit wound healing or promote super-bacterial infections.

Side effects:

There are no known side effects. Animals may have a desire to lick the solution from the wounds as they may be attracted to the sugars and salts. This may be desirable in some cases as they are naturally debriding the wound. The sugars and salts in the solution are natural dietary ingredients and are not harmful if swallowed in small amounts.

Caution:

For Veterinary Use Only. Not to be used on animals intended for food.  Keep out of the reach of children.

1. Swerczek, T.W.: Inhibition of the CEM Organism by the Normal Flora of the Reproductive Tract. Vet. Rec. 1978, 103:125.

2. Swerczek, T.W.: Personal communications.

3. King, S.S. et.al.: Use of specific sugars to inhibit bacterial adherence to equine endometrium in vitro. AJVR, 2000, 61; 446-449.

4. White,G.: Maltodextran, NF powder a new concept in equine wound healing. J. Equine Vet Sci. 1995, 15, 296-298.