 Composition:
Each 100 cc contains 20 grams of mannose and other monosaccharide sugars; 0.85
grams of sodium chloride, natural trace essential minerals from sea salts,
buffered with sodium salts of organic acids and purified water.
Action: The principle of this monosaccharide solution is based on
research which showed normal bacterial flora utilized monosaccharide metabolites
to naturally inhibit pathogenic bacteria of the skin and mucous membranes 1.
Further research demonstrated that these monosaccharide sugars and their
metabolites may be used to inhibit common pathogenic bacteria and fungi of the
reproductive tract of mares. Research by other workers has confirmed that
specific sugars can indeed prevent pathogenic bacteria from infecting mucosal
and epithelial cells of the reproductive tract of mares.2 . Also, it has been
proven that that adequate sodium is essential for optimum reproductive
fertility. An increase in sodium in the cervico-vaginal mucus is required during
estrus for high conception rates. 3 A deficiency in sodium increases infertility
and embryonic mortality 4,5 . UterineAde™ solutions contain natural sodium sea
salts.
Indications: For post foaling or aborting infected mares, the product may
be used with other fluids and antibiotics. For the most efficient use of the
product, other fluids such as saline lavage solutions may be used to remove
debris from the uterus. After the debris and fluid are removed, infuse the
uterus with undiluted UterineAde™. UterineAde™ will promote the contraction of
the uterus and will aid in clearing the uterus of excessive fluid. Use
UterineAde™daily until the uterus returns to normal.
Dosage and administration: For post-foaling and infected mares, 100 to
500 cc intrauterine, undiluted, per day, repeat daily until infection clears.
For mares to be bred, 60 to 100 cc per day on the first day of estrus, repeat
daily if necessary. Do not use the day of breeding. May be used 24 to 48 hours
post-breeding.
This protocol will aid in the prevention of venereal bacterial infections. This
product has been formulated to be used without antibiotics. However, systemic
antibiotics and other conventional treatments are recommended in addition to
UterineAde™ if post foaling or aborting mares are infected with pathogenic
microorganisms to aid in the prevention of septicemia and laminitis.
Although UterineAde can me used without antibiotics, it can also be used
in conjunction with antibiotics to aid in the healing of lesions while
neutralizing microbial organisms. UterineAde will neutralize the
microbial organisms if the bacteria are resistant to the antibiotics and may
also allow antibiotics to be more effective. UterineAde not only will
neutralize pathogens, but has the added benefit of healing lesions in the
uterine mucosa.Caution: For veterinary use only. Not to be used on animals intended for
food. Keep out of the reach of children.
Side effects: There are no known side effects.
References:
1. Swerczek, T.W.: Inhibition of the CEM organism by the Normal Flora of the
Reproductive Tract. Vet. Rec. 1978, 103:125.
2. King, S.S. et.al.: Use of specific sugars to inhibit bacterial adherence to
equine endometrium in vitro. AJVR. 2000, 61:446-449
3. Arya, S.P. and Jain, Y.C.: 1986. Sodium and potassium concentrations of
cervico-vaginal mucus in relation to oestrous cycle and early pregnancy
in Jersey cows. Indian Journal of Animal Science. 56:331.
4. Harris, D.J., Allen, J.D., and Caple, I.W.: 1986. Effects of low sodium
nutrition on fertility of dairy cows. Proceeding of the
Nutritional Society of Australia 11:92.
5. Cromwell, G.L., Hall, D.D. Combs, O.M. et.al.: 1989. Effects of dietary salt
level during gestation and lactation on reproductive
performance of sows. A cooperative study. J. Animal Science. 67:374.
Mechanism of action for intrauterine sugar solutions
Scientific Literature
Monosaccharide sugars have been shown to be effective in inhibiting bacteria
that commonly infect the genital-urinary tract of mares. One of the benefits of
sugars is that they can be used alone or with antibiotics to treat uterine
infections in mares. Specific sugars can inhibit bacterial adherence to the
equine endometrium in vitro. Mannose and N-acetyl-D-galactosamine inhibited
adhesion of Escherichia coli and Pseudomonas aeruginosa to epithelial cells,
whereas only mannose inhibited adhesion of Streptococcus zooepidemicus. In
horses with uterine infections, use of sugars to competitively displace bacteria
from attachment sites on cells may provide an adjunct to antibiotic treatment. 1
Bacterial adherence to cell surfaces and phagocytosis of bacteria is important
as it relates to pathogenicity of various strains of bacteria which are common
causes of uterine infections including Escherichia coli, Pseudomonas aruginosia,
Streptococcus zooepidemicus, Salmonella spp., and other bacteria. The adherence
of bacteria is inhibited by sugars such as L-fructose and D-galactose, which
suggest that sugar-mediated adherence is widespread. The intercellular
recognition is thought to be mediated by sugar residues such a D-mannose on the
surface of cells to which bacteria attach by sugar-binding substance of their
surface. The nature of the receptors is unknown, but there is evidence that
bacteria, like E. coli produces lectin-like substances specific for D-mannose,
by which it binds to the cells. 2
1. King SS, Young DA, Nequin LG, Carnevale EM. Use of specific sugars to inhibit
bacterial adherence to equine endometrium in vitro. Am J Vet Res. 2000
;61:446-9.
2.. Sharon N, Eshdat Y, Silverblatt FJ, Ofek I. Bacterial adherence to cell
surface sugars. Ciba Found Symp. 1981;80:119-41.
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