Professor T.W. Swerczek, a veterinary pathologist at the University of Kentucky had observed several years ago that the overuse of antibiotics would lead to antibiotic resistant super bacterial infections. Currently, there are bacteria and fungi that are resistant to nearly all antibiotics. Dr. Swerczek was the first to isolate the Contagious Equine Metritis (CEM) organism in the USA and showed that antibiotic resistant CEM bacteria had developed. He used the bacterium as a model to study and develop monosaccharide sugars, and their antibacterial derivatives as natural alternatives to antibiotics for the prevention and treatment of bacterial and fungal infections of the skin and reproductive tract.
While working on alternatives to antibiotics to treat resistant bacteria and super-bacterial infections of the reproductive tract of horses, Dr. Swerczek developed a solution for wound healing. He also observed several years ago that many of the commonly used antibiotics and disinfectants would not only induce resistance, but inhibited wound healing. Currently, in human medicine, they are coming to the same conclusion, and now are recommending that wounds should be washed with sterile water or saline and then kept dry for best wound healing. Unfortunately, because of the emergence of resistant, super-bacterial infections, like Staphylococcus, this is not always possible, and even more potent antibiotics are necessary to threat these life-threatening infections that may become systemic. Similarly, unlike humans, it is not possible to keep animal wounds clean and dry as they are commonly exposed to opportunistic and pathogenic organisms in the environment that contaminate wounds.
Professor T.W. Swerczek
Dr. Swerczek’s son Timothy M. Swerczek, BS. JD. is president and CEO of Woundade Inc. This company manufactures Woundade, and UterineAde
History of the Development of Woundade and UterineAdeSolutions.
Woundade, like so many discoveries in science, was discovered by accident and the reason why it works so dramatically to accelerate wound healing is still a mystery.
The solution of sugars in UterineAde was originally developed to treat venereal diseases of horses. The discovery that normal flora of the reproductive tract of horses utilize monosaccharide sugars to produce sugar-derived metabolites, which in turn inhibit pathogenic bacteria 1, is likely an important mechanism of action. These natural antibacterial monosaccharide derivatives are the basis for the development of UterineAde solutions
Since most wounds are infected with multiple opportunistic and pathogenic bacteria, the solution was tested on traumatic wounds, many of which were infected. The expected occurred in that the solution was highly effective in inhibiting the proliferation of bacteria in the infected wounds. But, in addition, the solution remarkablely accelerated all phases important for wound healing, namely contraction of the fresh wound, vascularization and epithelization. Also, the solutions prevented excessive granulation tissue, scarring, and the hair grew back the same color at the wound site.
Since the wound healing properties of the solution were serendipitous, the mechanism of action by which the solution accelerates wound healing is unknown. The most logical explanation, Woundade and UterineAde solutions seemingly provide nutrients for the body’s cellular structures and functions to naturally inhibit pathogens and to promote wound healing by stimulating the epithelial and mucosal cells to produce natural secretions and mucus.
Since it was obvious to equine practitioners that the novel solution induced wound healing unlike any other therapies for wound healing in horses, there was a great demand for the solution, especially for horses since their wounds are more difficult to heal than other animals.
Currently, there is considerable interest in using mannose, a monosaccharide sugar, as an aid for the treatment of urinary tract infections in humans and for reproductive tract infections in mares.2 Woundade and UterineAde solutions are broad spectrum in action as they not only contain the monosaccharide sugar, mannose, but other monosaccharide sugars, natural mineralized sea salts, and organic natural nutritional sodium salts.
Recent research has proven that that adequate sodium is essential for optimum reproductive fertility. An increase in sodium in the cervico-vaginal mucus is required during estrus for high conception rates. 3 A deficiency in sodium increases infertility and embryonic mortality4,5 . Woundade and UterineAde solutions contain natural sodium sea salts.
1. Swerczek, T.W.: Inhibition of the CEM organism by the Normal Flora of the Reproductive Tract. Vet. Rec. 1978, 103:125.
2. King, S.S. et.al.: Use of specific sugars to inhibit bacterial adherence to equine endometrium in vitro. AJVR. 2000, 61:446-449
3. Arya, S.P. and Jain, Y.C.: 1986. Sodium and potassium concentrations of cervico-vaginal mucus in relation to oestrous cycle and early pregnancy
in Jersey cows. Indian Journal of Animal Science. 56:331.
4. Harris, D.J., Allen, J.D., and Caple, I.W.: 1986. Effects of low sodium nutrition on fertility of dairy cows. Proceeding of the Nutritional Society of Australia 11:92.
5. Cromwell, G.L., Hall, D.D. Combs, O.M. et.al.: 1989. Effects of dietary salt level during gestation and lactation on reproductive performance of sows. A cooperative study. J. Animal Science. 67:374.